Thursday, November 29, 2012

DEA probes Walgreens pharmacies over drug diversion in Florida

(Reuters) - The U.S. Drug Enforcement Administration is probing three Walgreen Co pharmacies in Florida in connection with a wide-ranging investigation of the diversion of prescription drugs for illicit use.

The Miami Field Division of the DEA issued the pharmacies with orders to show cause - notifications that are given to facilities requiring them to prove why they should be allowed to keep their licenses.

The pharmacies affected are Walgreens #04727 in Fort Pierce; Walgreens #03629 in Hudson; and Walgreens #06997 in Oviedo.

The actions by the DEA do not immediately prevent the pharmacies from handling or distributing potentially addictive controlled substances such as sedatives and narcotic pain-killers.

However, Special Agent in Charge Mark R. Trouville, of the DEA's Miami Field Division, said the diversion of prescription drugs continues to be a "great concern for the DEA."

A spokesman for Walgreens, Jim Graham, said the company stopped accepting prescriptions for certain controlled substances at these pharmacies last May in a bid to show its willingness to work with the DEA.

"We have taken a number of steps since mid-2011 to enhance our monitoring and reporting criteria," he said in an e-mail. "These actions have resulted in a 35 percent drop in the number of tablets dispensed by our pharmacies in Florida for the most commonly abused pain management drug between June 2011 and March 2012."

The pharmacy's actions have included enhancing its ordering and inventory reporting requirements to limit quantities of several controlled substances with high risk potential, Graham said.

In April the DEA said it would inspect six Walgreens pharmacies and its Florida distribution center after the agency noticed a jump in purchases of the painkiller oxycodone. On September 14, the distribution center's registration was suspended. An administrative hearing is scheduled to begin on that matter on January 7, 2013.

The DEA has been ratcheting up its focus on drug wholesalers and pharmacies over the past year as attempts to battle what the Centers for Disease Control and Prevention calls a prescription drug abuse epidemic. Deaths from narcotic pain-killers now exceed those of heroin and cocaine combined.

Florida has long been considered the epicenter of prescription drug abuse and the DEA has dismantled dozens of "pill mills" - sham pain clinics whose doctors write prescriptions for thousands of pain pills to drug dealers and addicts.

The DEA said the pharmacies who received the orders may file a written request with the agency within 30 days for an opportunity to have an administrative hearing to determine whether their right to sell controlled substances should be revoked.

(Reporting by Toni Clarke; Editing by Andrew Hay and Dan Grebler)

Source: http://news.yahoo.com/dea-probes-walgreens-pharmacies-prescription-drugs-florida-205157560--finance.html

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Floods claim fourth life and leave worst insurance bills for five years ...

I?m glad it is/was not as bad as it could have been. I am a little confused, though, from the report, what is ?exceptionally high? water? Didn?t these floods count?
It seems that, as the flood patterns are so well known and prepared for, that there would not be any homes in the flood areas. But then, here, in the south east coastal USA, it seems that after every hurricane people rush to rebuild houses on coastal sand or even tiny, small islands that are only temporary and little sand spits that they know will overwash in a storm. Not only is this construction wasteful, but the post storm wrecks leave things, like boards with nails, buried in the sand. Unseen hazards to bare feet, at the least.

Source: http://theextinctionprotocol.wordpress.com/2012/11/28/floods-claim-fourth-life-and-leave-worst-insurance-bills-for-five-years/

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Google acquires coupon-focused Incentive Targeting for undisclosed sum

Google acquires couponfocused Incentive Targeting for undisclosed sum

Google is no stranger to the business of discounts and special offers, but it looks like it's decided to reach outside the company to further bolster its offerings. The company confirmed today that it has acquired the Cambridge, Massachusetts-based marketing firm Incentive Targeting for an undisclosed sum. While not offering too much in the way of specifics, Google said in a statement that "we look forward to working with Incentive Targeting in our ongoing efforts to help consumers save time and money and enable retailers deliver relevant discounts to the right customers." For its part, Incentive Targeting has said that it "set out to do for retail couponing what Google had done for online advertising: make it simple, relevant, measurable, and effective," and to that end it has developed a variety of tools for retailers and manufacturers alike, all designed to deliver coupons and discounts in a more targeting manner. You can find the company's full statement on its website.

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Jenna Bush Hager Hired as Editor at Southern Living

Source: http://www.thehollywoodgossip.com/2012/11/jenna-bush-hager-hired-as-editor-at-southern-living/

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Wednesday, November 28, 2012

2 men sentenced in Fast and Furious gun case

PHOENIX (AP) ? Two men were sentenced Monday for their roles in a gun smuggling ring that was part of the U.S. government's botched Operation Fast and Furious, an investigation that unraveled after illegally purchased weapons turned up at the scene of a fatal Border Patrol agent shooting.

Jacob Anthony Montelongo was sentenced in federal court in Phoenix to nearly 3 1/2 years in prison after pleading guilty to conspiracy and dealing guns without a license. Sean Christopher Steward received a nine-year sentence for conspiracy and making false statements to authorities.

According to the U.S. Justice Department, Steward and Montelongo were among so-called straw buyers who illegally purchased weapons for traffickers and Mexican drug cartels in a wide-ranging Phoenix-based gun trafficking ring.

In Operation Fast and Furious, agents from the Bureau of Alcohol, Tobacco, Firearms and Explosives used a controversial tactic called gun-walking, where instead of intercepting all weapons believed to be purchased illegally almost immediately, they wanted to track the guns back to high-level arms traffickers who had long eluded prosecution, in an effort to dismantle their networks.

But federal agents lost track of many of the guns purchased at Arizona shops before they ended up in Mexico, where many of them have been recovered at crime scenes. The operation ultimately identified more than 2,000 illicitly purchased weapons, and some 1,400 of them have yet to be found.

Two guns in Operation Fast and Furious were found on the U.S. side of the border at the scene of the 2010 fatal shooting of Border Patrol Agent Brian Terry.

Five men have since been charged in Terry's death. One pleaded guilty last month and faces life in prison. Three others remain fugitives.

In his guilty plea, Manuel Osorio-Arellanes admitted he was part of a rip-off crew that sneaked into the United States from Mexico about a week before Terry's death. He said they stashed guns and food supplies on the U.S. side of the border, aiming to rob marijuana smugglers and illegal immigrants.

Operation Fast and Furious has led to widespread congressional criticism. President Barack Obama has invoked executive privilege in the case, and Attorney General Eric Holder has been found to be in contempt of Congress.

Twenty people were initially indicted in the overall weapons case, including Montelongo and Steward, who authorities say were among the most prolific of the straw buyers. They were accused of illegally purchasing hundreds of firearms sold to criminals in Mexico, including associates of major Mexican drug cartels.

Steward is accused of paying more than $176,000 provided by the leader of a gun trafficking organization to purchase nearly 290 weapons, including high-powered rifles. Authorities say Montelongo illegally bought and assisted in the purchase of 109 firearms.

Steward's attorney, Diego Rodriguez, said he plans to appeal his client's sentence. Montelongo's attorney did not return telephone calls or emails seeking comment.

Source: http://news.yahoo.com/2-men-sentenced-fast-furious-gun-case-003328560--politics.html

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China party mouthpiece ridiculed after missing "sexy" Kim joke

SHANGHAI (Reuters) - Tongue-in-cheek clearly doesn't come naturally to the Chinese Communist Party's official mouthpiece and the stodgy People's Daily faced ridicule on Wednesday for missing a joke about North Korea's leader.

The newspaper's website published an extensive photo spread of pudgy North Korean leader Kim Jong-un on Tuesday, apparently falling for a spoof report by the satirical U.S.-based website The Onion naming Kim the "Sexiest Man Alive for 2012".

It certainly amused readers - though perhaps not as intended.

The photo spread was re-posted and commented on more than 25,000 times by Wednesday afternoon on the Sina Weibo microblogging site.

"Now I understand our party's aesthetical standards," said a blogger by the name of "butterfinger".

The People's Daily website, run separately from the print version, did not mention in photo captions or text if it understood the satirical nature of The Onion, and an editor reached by telephone declined to comment.

"This was just a normal report. We covered The Onion's report objectively and factually," he said.

If the spoof article was mistaken for being genuine it would not be a first for China's tightly controlled media.

In 2002, the Beijing Evening News ran a story quoting The Onion about the U.S. Congress threatening to leave Washington D.C. for Memphis or Charlotte unless the city gave it a new Capitol building with a retractable dome.

To some readers the Kim spread - which showed him riding horses, shaking soldiers' hands, clapping, waving - was an embarrassment.

"The People's Daily congratulates Mr. Kim Jung-un as the sexiest man in the world and the whole world is laughing," microblogger "Fu Laidi" said on Weibo.

"I just want to know if the editor was fired or not ... according to China's news rules, this is a very serious accident ... all the foreign media are laughing at us," wrote "Zhen Ye Ku Shami".

At least one user took pity on the People's Daily.

"You know how hard it is to pick positive news about North Korea?" wrote "Hacintosh". "When they finally find one, no matter what, they just put it on online."

The People's Daily print edition feeds readers a steady diet of pro-forma propaganda, including reports on the activities of China's leaders, texts of state policies and feel-good tales of model workers.

But the website has been given a long leash in some sections to pull in readers.

Other items in the photo section where the Kim report appeared, included "Stunning video: boa pukes out cow", "Celebs and their kids", and "'Sex Tape' official at work".

The Onion, meanwhile, updated its story with a link to the People's Daily photo spread, calling the paper "a proud Communist subsidiary of The Onion, Inc." http://www.theonion.com/articles/kim-jongun-named-the-onions-sexiest-man-alive-for,30379/

"Exemplary reportage, comrades," it said.

(Reporting by Koh Gui Qing; Writing by John Ruwitch; Editing by Jason Webb and Robert Birsel)

Source: http://news.yahoo.com/china-party-mouthpiece-may-eat-crow-sexy-kim-094640205.html

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Tuesday, November 27, 2012

UK Criminal Law ? Through the Stages | Criminal Defence Blawg

Going through a criminal case can be a very stressful and worrying time, especially if it is your first time. We hope that knowing what to expect will help you through the stages of criminal investigation / prosecution.

At the Police Station

If you are suspected of committing a criminal offence you may be either arrested or invited for an interview under caution at a police station. What happens at the police station can often to vital to future proceedings and therefore you should be representation from a specialist criminal law firm such as MJP solicitors. In the UK you are entitled to free legal advice from a solicitor ? do not answer any questions until you have a solicitor present.

The solicitor representing you will be given information about the allegations, without the client present ? this is called disclosure. They will then discuss with you the information they have received and offer advice on how to proceed with the interview. This conversation is confidential.

Once you have spoken to the solicitor you will then be interviewed. The interview is recorded and you will be cautioned.

Once the interview is over you may be charged, bailed to a later date, summonsed or no further action will be taken. Depending on your outcome the solicitor will talk you through the next stages of the investigation, if there are any.

At the Magistrates? Court

There are two types of offences which can be tried at the Magistrates? Court; Summary Only and Either Way offences.

Summary only offences are typically minor offences, such as motoring offences. Either way offences are generally more serious offences, such as burglary, and can also be dealt with in the Crown Court.

Depending on your financial circumstances you may entitled to legal aid which means you can be represented for free.

What happens at the first appearance depends on the offence, this is something your solicitor will offer advice on. If the offence is serious it may be committed to the Crown Court. The court may adjourn the case to a later date so that you can prepare a defence, or the prosecution can prepare their evidence. For less serious offences the matter maybe dealt with on the day but, of course, it all depends if you wish to plead guilty or not guilty.

If you plead guilty you are entitled to a third of the sentence ? this applies to fines, community orders and sentences of imprisonment.

If you plead not guilty your trial can take place within the Magistrates? Court (at a later date). A trial here is slightly different to a Crown Court trial as there is no jury. The prosecution put forward their evidence to the judge followed by the defence putting forward their argument on your behalf, this may include the use of witnesses.

After all the evidence is given the judge, or judges, will then retire to consider their verdict.

At the Crown Court

The Crown Court can be considered as the next step up from the Magistrates? Court.

If you have elected to go to trial the case will take place before 12 members of the jury. In short the prosecution will put forward their evidence to the jury, followed by your barrister putting forward your defence to them.

The judge will then summarise the arguments put forward for the jury and then the jury leave the court to discuss the evidence and come to a decision. If the jury can not unanimously decide on a verdict (they all agree the same) and a period of time has passed then a majority verdict will be accepted.

If you are found guilty, or have pleaded guilty, your barrister will mitigate on your behalf putting forward your circumstances to get the best possible sentence.

About the author: MJP solicitors are a criminal defence practice based in the UK who defending clients against allegations of criminal offences.

No related posts.

Source: http://www.criminaldefenceblawg.com/criminal-defence-law/uk-criminal-law-through-the-stages/

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Novel power system for space travel tested

ScienceDaily (Nov. 26, 2012) ? A team of researchers, including engineers from Los Alamos National Laboratory, has demonstrated a new concept for a reliable nuclear reactor that could be used on space flights.

The research team recently demonstrated the first use of a heat pipe to cool a small nuclear reactor and power a Stirling engine at the Nevada National Security Site's Device Assembly Facility near Las Vegas. The Demonstration Using Flattop Fissions (DUFF) experiment produced 24 watts of electricity. A team of engineers from Los Alamos, the NASA Glenn Research Center and National Security Technologies LLC (NSTec) conducted the experiment.

Heat pipe technology was invented at Los Alamos in 1963. A heat pipe is a sealed tube with an internal fluid that can efficiently transfer heat produced by a reactor with no moving parts. A Stirling engine is a relatively simple closed-loop engine that converts heat energy into electrical power using a pressurized gas to move a piston. Using the two devices in tandem allowed for creation of a simple, reliable electric power supply that can be adapted for space applications.

Researchers configured DUFF on an existing experiment, known as Flattop, to allow for a water-based heat pipe to extract heat from uranium. Heat from the fission reaction was transferred to a pair of free-piston Stirling engines manufactured by Sunpower Inc., based in Athens Ohio. Engineers from NASA Glenn designed and built the heat pipe and Stirling assembly and operated the engines during the experiment. Los Alamos nuclear engineers operated the Flattop assembly under authorization from the National Nuclear Security Administration (NNSA).

DUFF is the first demonstration of a space nuclear reactor system to produce electricity in the United States since 1965, and the experiment confirms basic nuclear reactor physics and heat transfer for a simple, reliable space power system.

"The nuclear characteristics and thermal power level of the experiment are remarkably similar to our space reactor flight concept," said Los Alamos engineer David Poston. "The biggest difference between DUFF and a possible flight system is that the Stirling input temperature would need to be hotter to attain the required efficiency and power output needed for space missions."

"The heat pipe and Stirling engine used in this test are meant to represent one module that could be used in a space system," said Marc Gibson of NASA Glenn. "A flight system might use several modules to produce approximately one kilowatt of electricity."

Current space missions typically use power supplies that generate about the same amount of electricity as one or two household light bulbs. The availability of more power could potentially boost the speed with which mission data is transmitted back to Earth, or increase the number of instruments that could be operated at the same time aboard a spacecraft.

"A small, simple, lightweight fission power system could lead to a new and enhanced capability for space science and exploration," said Los Alamos project lead Patrick McClure. "We hope that this proof of concept will soon move us from the old-frontier of Nevada to the new-frontier of outer space."

Los Alamos research on the project was made possible through Los Alamos's Laboratory-Directed Research and Development Program (LDRD), which is funded by a small percentage of the Laboratory's overall budget to invest in new or cutting-edge research. NASA Glenn and NSTec also used internal support to fund their contributions to the experiment.

"Perhaps one of the more important aspects of this experiment is that it was taken from concept to completion in 6 months for less than a million dollars," said Los Alamos engineer David Dixon. "We wanted to show that with a tightly-knit and focused team, it is possible to successfully perform practical reactor testing."

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Wall St edges down after recent rally; retailers weigh

NEW YORK (Reuters) - Wall Street slipped on Monday, pulling back from last week's gains, as retailers fell on concerns about heavy discounts at the start of the U.S. holiday shopping season and the overhang of the "fiscal cliff" kept investors wary of making big bets.

The Nasdaq outperformed to close higher, led by gains in eBay and as Apple continued its bounce back.

The Standard & Poor's 500 cut most of its losses during the session and managed to stay above the psychologically important 1,400 level. It also remained above the 200-day moving average, maintaining its long-term uptrend.

The S&P 500 consumer discretionary index <.gspd> fell 0.5 percent after the start of the holiday shopping season over the four-day Thanksgiving weekend. Target , one of the largest retailers by market value, fell 2.6 percent.

"The concern is big retailers are discounting so much, sales look better, but at what cost?" said Angel Mata, managing director of listed equity trading at Stifel Nicolaus Capital Markets in Baltimore.

Bucking the retail trend, shares of eBay closed at their highest in almost eight years, rising 4.9 percent to $51.40, as the online marketplace notched strong sales on "Cyber Monday." Amazon gained 1.6 percent to $243.62.

The White House threw cold water on a proposal of avoiding the looming "fiscal cliff" of spending cuts and tax highs by limiting tax deductions and loopholes, instead of allowing tax rates to rise for the richest Americans.

Investors are hoping for advances in talks over the $600 billion in spending cuts and tax hikes scheduled to begin next year, which threaten to drag the U.S. economy back into recession.

Indications of progress in talks, or just political willingness to negotiate, contributed to the market's recent rally. Major indexes last week gained 3 to 4 percent, with the Dow above 13,000 and the S&P above 1,400 for the first time since November 6.

Those gains represented a turnaround from recent losses founded on worries about Washington's ability to solve budgetary problems.

The Dow Jones industrial average <.dji> fell 42.31 points, or 0.33 percent, to 12,967.37. The S&P 500 <.spx> dropped 2.86 points, or 0.20 percent, to 1,406.29. The Nasdaq Composite <.ixic> gained 9.93 points, or 0.33 percent, to 2,976.78.

About 5.2 billion shares changed hands on the New York Stock Exchange, the Nasdaq and NYSE MKT, below the daily average so far this year of about 6.49 billion shares.

On the NYSE, roughly 13 issues fell for every 10 that rose, and on Nasdaq nearly six rose for every five that fell.

In the other major worry for the market, euro zone finance ministers and the International Monetary Fund made their third attempt in as many weeks to agree on releasing emergency aid for Greece, with policymakers saying a write-down of Greek debt is off the table for now.

"There's no catalyst to continue the rally we saw last week, though Greece would have been important if we weren't dealing with the fiscal cliff," Stifel Nicolaus' Mata said.

Shares of Knight Capital Group Inc jumped 13.3 percent to $2.82 following reports that rivals might be preparing to bid for part or all of the trading firm.

Apple Inc has asked a federal court to add six more products to its patent infringement lawsuit against Samsung Electronics , including the Samsung Galaxy Note II, in the latest move in an ongoing legal war between the two companies. Apple shares were up 3.2 percent at $589.53.

(Reporting by Rodrigo Campos; Editing by Leslie Adler)

Source: http://news.yahoo.com/wall-st-slips-recent-rally-retailers-off-204334828--sector.html

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Refresh Roundup: week of November 19th, 2012

Your smartphone and / or tablet is just begging for an update. From time to time, these mobile devices are blessed with maintenance refreshes, bug fixes, custom ROMs and anything in between, and so many of them are floating around that it's easy for a sizable chunk to get lost in the mix. To make sure they don't escape without notice, we've gathered every possible update, hack, and other miscellaneous tomfoolery we could find during the last week and crammed them into one convenient roundup. If you find something available for your device, please give us a shout at tips at engadget dawt com and let us know. Enjoy!

Continue reading Refresh Roundup: week of November 19th, 2012

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/wqQdnXol7Og/

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Illinois sets March election to replace Jesse Jackson Junior

CHICAGO (Reuters) - Illinois has set a date of March 19 for a special election to fill the U.S. congressional seat vacated by Democrat Jesse Jackson Jr., who resigned last week amid an ethics investigation and concerns over his health.

Illinois Governor Pat Quinn announced the date in a statement on Monday but said the special election may be delayed a few weeks to coincide with local elections in April.

Quinn also said the primary election for the seat will be held on February 26. The winner of the Democratic primary will be the favorite in the general election because the majority African-American district is solidly Democratic.

Even before Quinn set the dates, a number of people were said to be contemplating a run for the seat, according to local media reports. They include including former U.S. Representative Debbie Halvorson, former Cook County Board President Todd Stroger, Pastor Corey Brooks and lawyer Sam Adam Jr.

In his two-page resignation letter on Wednesday, Jackson, 47, who has been treated for bipolar disorder and is reportedly under investigation for possible misuse of campaign funds, acknowledged he was the target of a federal probe and in possible plea talks.

"I am aware of the ongoing federal investigation into my activities and I am doing my best to address the situation responsibly, cooperate with the investigators and accept responsibility for my mistakes," Jackson wrote.

Jackson, who has been in Congress since 1995, easily won re-election earlier this month despite the growing ethics questions.

His resignation did not result in any change in the political balance of power of the U.S. House of Representatives, which has a solid Republican majority.

Jackson was treated for at least six weeks this summer at the Mayo Clinic in Rochester, Minnesota, for bipolar disorder, a psychological condition marked by extreme mood swings.

He has also been the subject of a House ethics committee probe over an alleged bribe offered by a Jackson supporter in 2008 to then Illinois Governor Rod Blagojevich.

The bribe was said to be intended to entice Blagojevich to appoint Jackson to the U.S. Senate seat vacated by President Barack Obama. Jackson has admitted to lobbying for the seat but denied knowing about any money offered to Blagojevich, who has since been convicted on corruption charges and imprisoned.

According to news reports citing unnamed sources, Jackson is also being investigated by the FBI over possible misuse of campaign money. The FBI has not confirmed the reports.

(Reporting by James B. Kelleher; Editing by Greg McCune and Eric Beech)

Source: http://news.yahoo.com/illinois-sets-march-election-replace-jesse-jackson-junior-222705407.html

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Monday, November 26, 2012

ScienceDaily: Gene News

ScienceDaily: Gene Newshttp://www.sciencedaily.com/news/health_medicine/genes/ Genes and Genetics News. Read today's medical research in genetics including what can damage genes, what can protect them, and more.en-usSun, 25 Nov 2012 11:42:30 ESTSun, 25 Nov 2012 11:42:30 EST60ScienceDaily: Gene Newshttp://www.sciencedaily.com/images/logosmall.gifhttp://www.sciencedaily.com/news/health_medicine/genes/ For more science articles, visit ScienceDaily.New molecular culprit linked to breast cancer progressionhttp://www.sciencedaily.com/releases/2012/11/121124090511.htm Researchers have uncovered a protein ?partner? commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery details how some tumors get the tools they need to metastasize.Sat, 24 Nov 2012 09:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121124090511.htmNew insights into virus proteome: Unknown proteins of the herpesvirus discoveredhttp://www.sciencedaily.com/releases/2012/11/121123092132.htm The genome encodes the complete information needed by an organism, including that required for protein production. Viruses, which are up to a thousand times smaller than human cells, have considerably smaller genomes. Using a type of herpesvirus as a model system scientists have shown that the genome of this virus contains much more information than previously assumed. The researchers identified several hundred novel proteins, many of which were surprisingly small.Fri, 23 Nov 2012 09:21:21 ESThttp://www.sciencedaily.com/releases/2012/11/121123092132.htmScientists describe elusive replication machinery of flu viruseshttp://www.sciencedaily.com/releases/2012/11/121122152928.htm Scientists have made a major advance in understanding how flu viruses replicate within infected cells. The researchers used cutting-edge molecular biology and electron-microscopy techniques to ?see? one of influenza?s essential protein complexes in unprecedented detail. The images generated in the study show flu virus proteins in the act of self-replication, highlighting the virus?s vulnerabilities that are sure to be of interest to drug developers.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152928.htmProtein folding: Look back on scientific advances made as result of 50-year old puzzlehttp://www.sciencedaily.com/releases/2012/11/121122152910.htm Fifty years after scientists first posed a question about protein folding, the search for answers has led to the creation of a full-fledged field of research that led to major advances in supercomputers, new materials and drug discovery, and shaped our understanding of the basic processes of life, including so-called "protein-folding diseases" such as Alzheimer's, Parkinson's and type II diabetes.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152910.htmStep forward in regenerating and repairing damaged nerve cellshttp://www.sciencedaily.com/releases/2012/11/121121145638.htm Researchers recently uncovered a nerve cell's internal clock, used during embryonic development. This breakthrough could lead to the development of new tools to repair and regenerate nerve cells following injuries to the central nervous system.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145638.htmArchitecture of rod sensory cilium disrupted by mutationhttp://www.sciencedaily.com/releases/2012/11/121121145621.htm Using a new technique called cryo-electron tomography, scientists have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium (part of one type of photoreceptor in the eye) is changed by genetic mutation and how that affects its ability to transport proteins as part of the light-sensing process.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145621.htmAging: Scientists further unravel telomere biologyhttp://www.sciencedaily.com/releases/2012/11/121121130933.htm Researchers have resolved the structure of that allows a telomere-related protein, Cdc13, to form dimers in yeast. Mutations in this region of Cdc13 put the kibosh on the ability of telomerase and other proteins to maintain telomeres.Wed, 21 Nov 2012 13:09:09 ESThttp://www.sciencedaily.com/releases/2012/11/121121130933.htmDrug resistance biomarker could improve cancer treatmenthttp://www.sciencedaily.com/releases/2012/11/121121130811.htm Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reported in a new study. The study reveals a biomarker that can predict responses to cancer drugs and offers a strategy to treat drug-resistant tumors based on their genetic signature.Wed, 21 Nov 2012 13:08:08 ESThttp://www.sciencedaily.com/releases/2012/11/121121130811.htmGenome packaging: Key to breast cancer developementhttp://www.sciencedaily.com/releases/2012/11/121121130703.htm Two recent studies delve into the role of chromatin modifying enzymes and transcription factors in tumour cells. In one, it was found that the PARP1 enzyme activated by kinase CDK2 is necessary to induce the genes responsible for the proliferation of breast cancer cells in response to progesterone. In another, extensive work has been undertaken to identify those genes activated by the administration of progesterone in breast cancer, the sequences that can be recognized and how these genes are induced.Wed, 21 Nov 2012 13:07:07 ESThttp://www.sciencedaily.com/releases/2012/11/121121130703.htmShort DNA strands in genome may be key to understanding human cognition and diseaseshttp://www.sciencedaily.com/releases/2012/11/121121130643.htm Previously discarded, human-specific ?junk? DNA represents untapped resource in the study of diseases like Alzheimer?s and autism.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130643.htmBiomarking time: Methylome modifications offer new measure of our 'biological' agehttp://www.sciencedaily.com/releases/2012/11/121121130633.htm In a new study, researchers describe markers and a model that quantify how aging occurs at the level of genes and molecules, providing not just a more precise way to determine how old someone is, but also perhaps anticipate or treat ailments and diseases that come with the passage of time.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130633.htmKidney tumors have a mind of their ownhttp://www.sciencedaily.com/releases/2012/11/121121104552.htm New research has found there are several different ways that kidney tumors can achieve the same result -- namely, grow.Wed, 21 Nov 2012 10:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121121104552.htmMechanism to repair clumped proteins explainedhttp://www.sciencedaily.com/releases/2012/11/121121104416.htm Clumped proteins can be dissolved with the aid of cellular repair systems -- a process of critical importance for cell survival especially under conditions of stress. Researchers have now decrypted the fundamental mechanism for dissolving protein aggregates that involves specific molecular chaperones.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104416.htmNovel mechanism through which normal stromal cells become cancer-promoting stromal cells identifiedhttp://www.sciencedaily.com/releases/2012/11/121121104401.htm New understanding of molecular changes that convert harmless cells surrounding ovarian cancer cells into cells that promote tumor growth and metastasis provides potential new therapeutic targets for this deadly disease, according to new research.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104401.htmNew test for tuberculosis could improve treatment, prevent deaths in Southern Africahttp://www.sciencedaily.com/releases/2012/11/121120194932.htm A new rapid test for tuberculosis (TB) could substantially and cost-effectively reduce TB deaths and improve treatment in southern Africa -- a region where both HIV and tuberculosis are common.Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194932.htmEvolution of human intellect: Human-specific regulation of neuronal geneshttp://www.sciencedaily.com/releases/2012/11/121120194926.htm A new study has identified hundreds of small regions of the genome that appear to be uniquely regulated in human neurons. These regulatory differences distinguish us from other primates, including monkeys and apes, and as neurons are at the core of our unique cognitive abilities, these features may ultimately hold the key to our intellectual prowess (and also to our potential vulnerability to a wide range of 'human-specific' diseases from autism to Alzheimer's).Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194926.htmRibosome regulates viral protein synthesis, revealing potential therapeutic targethttp://www.sciencedaily.com/releases/2012/11/121120132906.htm Rather than target RNA viruses directly, aiming at the host cells they invade could hold promise, but any such strategy would have to be harmless to the host. Now, a surprising discovery made in ribosomes may point the way to fighting fatal viral infections such as rabies.Tue, 20 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121120132906.htmHow does antibiotic resistance spread? Scientists find answers in the nosehttp://www.sciencedaily.com/releases/2012/11/121120121835.htm Microbiologists studying bacterial colonization in mice have discovered how the very rapid and efficient spread of antibiotic resistance works in the respiratory pathogen, Streptococcus pneumoniae (also known as the pneumococcus). The team found that resistance stems from the transfer of DNA between bacterial strains in biofilms in the nasopharynx, the area just behind the nose.Tue, 20 Nov 2012 12:18:18 ESThttp://www.sciencedaily.com/releases/2012/11/121120121835.htmScientists identify inhibitor of myelin formation in central nervous systemhttp://www.sciencedaily.com/releases/2012/11/121120100155.htm Scientists have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system. Myelin promotes the conduction of nerve cell impulses by forming a sheath around their projections, the so-called axons, at specific locations -- acting like the plastic insulation around a power cord.Tue, 20 Nov 2012 10:01:01 ESThttp://www.sciencedaily.com/releases/2012/11/121120100155.htm'Obese but happy gene' challenges the common perception of link between depression and obesityhttp://www.sciencedaily.com/releases/2012/11/121120084725.htm Researchers have discovered new genetic evidence about why some people are happier than others. The scientists have uncovered evidence that the gene FTO -- the major genetic contributor to obesity -- is associated with an eight per cent reduction in the risk of depression. In other words, it's not just an obesity gene but a "happy gene" as well.Tue, 20 Nov 2012 08:47:47 ESThttp://www.sciencedaily.com/releases/2012/11/121120084725.htmTelomere lengths predict life expectancy in the wild, research showshttp://www.sciencedaily.com/releases/2012/11/121119213144.htm Researchers have found that biological age and life expectancy can be predicted by measuring an individual's DNA. They studied the length of chromosome caps -- known as telomeres -- in a 320-strong wild population of Seychelles Warblers on a small isolated island.Mon, 19 Nov 2012 21:31:31 ESThttp://www.sciencedaily.com/releases/2012/11/121119213144.htmCancer: Some cells don't know when to stophttp://www.sciencedaily.com/releases/2012/11/121119171403.htm Certain mutated cells keep trying to replicate their DNA -- with disastrous results -- even after medications rob them of the raw materials to do so, according to new research.Mon, 19 Nov 2012 17:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121119171403.htmMultiple sclerosis ?immune exchange? between brain and blood is uncoveredhttp://www.sciencedaily.com/releases/2012/11/121119163301.htm DNA sequences obtained from a handful of patients with multiple sclerosis have revealed the existence of an ?immune exchange? that allows the disease-causing cells to move in and out of the brain.Mon, 19 Nov 2012 16:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121119163301.htmFruit fly studies guide investigators to molecular mechanism frequently misregulated in human cancershttp://www.sciencedaily.com/releases/2012/11/121119132056.htm Changes in how DNA interacts with histones ?- the proteins that package DNA ?- regulate many fundamental cell activities from stem cells maturing into a specific body cell type or blood cells becoming leukemic. These interactions are governed by a biochemical tug of war between repressors and activators, which chemically modify histones signaling them to clamp down tighter on DNA or move aside and allow a gene to be expressed.Mon, 19 Nov 2012 13:20:20 ESThttp://www.sciencedaily.com/releases/2012/11/121119132056.htm3-D light switch for the brain: Device may help treat Parkinson's, epilepsy; aid understanding of consciousnesshttp://www.sciencedaily.com/releases/2012/11/121119114249.htm A new tool for neuroscientists delivers a thousand pinpricks of light to individual neurons in the brain. The new 3-D "light switch", created by biologists and engineers, could one day be used as a neural prosthesis that could treat conditions such as Parkinson's and epilepsy by using gene therapy to turn individual brain cells on and off with light.Mon, 19 Nov 2012 11:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121119114249.htmNew factor of genetic susceptibility to Alzheimer's diseasehttp://www.sciencedaily.com/releases/2012/11/121119104944.htm A large-scale international study has just discovered a gene for susceptibility to a rare disease providing evidence of the heterogeneous aetiology of Alzheimer's disease.Mon, 19 Nov 2012 10:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121119104944.htmBlood cancer gene BCL6 identified as a key factor for differentiation of nerve cells of cerebral cortexhttp://www.sciencedaily.com/releases/2012/11/121119093848.htm The cerebral cortex is the most complex structure in our brain and the seat of consciousness, emotion, motor control and language. In order to fulfill these functions, it is composed of a diverse array of nerve cells, called cortical neurons, which are affected by many neurological and neuropsychiatric diseases. Researchers have opened new perspectives on brain development and stem cell neurobiology by discovering a gene called BCL6 as a key factor in the generation of cortical neurons during embryonic brain development.Mon, 19 Nov 2012 09:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121119093848.htmMinority report: Insight into subtle genomic differences among our own cellshttp://www.sciencedaily.com/releases/2012/11/121118141530.htm Scientists have demonstrated that induced pluripotent stem cells -- the embryonic-stem-cell look-alikes whose discovery a few years ago won this year's Nobel Prize in medicine -- are not as genetically unstable as was thought.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141530.htmSkin cells reveal DNA's genetic mosaichttp://www.sciencedaily.com/releases/2012/11/121118141524.htm The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141524.htmLikely basis of birth defect causing premature skull closure in infants identifiedhttp://www.sciencedaily.com/releases/2012/11/121118141432.htm Geneticists, pediatricians, surgeons and epidemiologists have identified two areas of the human genome associated with the most common form of non-syndromic craniosynostosis premature closure of the bony plates of the skull.Sun, 18 Nov 2012 14:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121118141432.htmDNA packaging discovery reveals principles by which CRC mutations may cause cancerhttp://www.sciencedaily.com/releases/2012/11/121117184658.htm A new discovery concerning a fundamental understanding about how DNA works will produce a "180-degree change in focus" for researchers who study how gene packaging regulates gene activity, including genes that cause cancer and other diseases.Sat, 17 Nov 2012 18:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121117184658.htmHepatitis C treatment's side effects can now be studied in the labhttp://www.sciencedaily.com/releases/2012/11/121116161059.htm Adverse side effects of certain hepatitis C medications can now be replicated in the lab, thanks to a research team. The new method aids understanding of recent failures of hepatitis C antiviral drugs in some patients, and could help to identify medications that eliminate adverse effects. The findings may aid the development of safer and more effective treatments for hepatitis C and other pathogens such as SARS and West Nile virus.Fri, 16 Nov 2012 16:10:10 ESThttp://www.sciencedaily.com/releases/2012/11/121116161059.htmReconsidering cancer's bad guyhttp://www.sciencedaily.com/releases/2012/11/121116124644.htm Researchers have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain.Fri, 16 Nov 2012 12:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121116124644.htmGene distinguishes early birds from night owls and helps predict time of deathhttp://www.sciencedaily.com/releases/2012/11/121116124551.htm New research shows that a gene is responsible for a person's tendency to be an early riser or night owl -- and helps determine the time of day a person is most likely to die.Fri, 16 Nov 2012 12:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121116124551.htmClues to cause of kids' brain tumorshttp://www.sciencedaily.com/releases/2012/11/121116091226.htm Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children.Fri, 16 Nov 2012 09:12:12 ESThttp://www.sciencedaily.com/releases/2012/11/121116091226.htmArthritis study reveals why gender bias is all in the geneshttp://www.sciencedaily.com/releases/2012/11/121115210541.htm Researchers have pieced together new genetic clues to the arthritis puzzle in a study that brings potential treatments closer to reality and could also provide insights into why more women than men succumb to the disabling condition.Thu, 15 Nov 2012 21:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121115210541.htmClass of RNA molecules protects germ cells from damagehttp://www.sciencedaily.com/releases/2012/11/121115172255.htm Passing one's genes on to the next generation is a mark of evolutionary success. So it makes sense that the body would work to ensure that the genes the next generation inherits are exact replicas of the originals. Biologists have now identified one way the body does exactly that.Thu, 15 Nov 2012 17:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121115172255.htmQuick test speeds search for Alzheimer's drugs: Compound restores motor function and longevity to fruit flieshttp://www.sciencedaily.com/releases/2012/11/121115152655.htm Researchers report that an efficient, high-volume technique for testing potential drug treatments for Alzheimer's disease uncovered an organic compound that restored motor function and longevity to fruit flies with the disease.Thu, 15 Nov 2012 15:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115152655.htmProtein-making machinery can switch gears with a small structural change process; Implications for immunity and cancer therapyhttp://www.sciencedaily.com/releases/2012/11/121115133414.htm For the past several years, research has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process of producing proteins. In a new study, scientists have shown that this enzyme can actually also work in another fundamental process in humans.Thu, 15 Nov 2012 13:34:34 ESThttp://www.sciencedaily.com/releases/2012/11/121115133414.htmPlant derivative, tanshinones, protects against sepsis, study suggestshttp://www.sciencedaily.com/releases/2012/11/121115133312.htm Researchers have discovered that tanshinones, which come from the plant Danshen and are highly valued in Chinese traditional medicine, protect against the life-threatening condition sepsis.Thu, 15 Nov 2012 13:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121115133312.htmStructure of enzyme topoisomerase II alpha unravelled providing basis for more accurate design of chemotherapeutic drugshttp://www.sciencedaily.com/releases/2012/11/121115132903.htm Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are important enzymes that are involved in maintaining the structure of DNA and chromosome segregation during both replication and transcription of DNA. One of these enzymes, topoisomerase II alpha, is involved in the replication of DNA and cell proliferation, and is highly expressed in rapidly dividing cancer cells.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132903.htmNewly discovered enzyme important in the spreading of cancerhttp://www.sciencedaily.com/releases/2012/11/121115132901.htm Enzyme hunters at UiO have discovered the function of an enzyme that is important in the spreading of cancer. Cancer researchers now hope to inhibit the enzyme.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132901.htmGenetics point to serious pregnancy complication, pre-eclampsiahttp://www.sciencedaily.com/releases/2012/11/121115132613.htm New research has revealed a genetic link in pregnant moms - and their male partners - to pre-eclampsia, a life-threatening complication during pregnancy.Thu, 15 Nov 2012 13:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115132613.htmMolecular mechanisms underlying stem cell reprogramming decodedhttp://www.sciencedaily.com/releases/2012/11/121115132344.htm Thanks to some careful detective work, scientist better understand just how iPS cells form ? and why the Yamanaka process is inefficient, an important step to work out for regenerative medicine. The findings uncover cellular impediments to iPS cell development that, if overcome, could dramatically improve the efficiency and speed of iPS cell generation.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132344.htmSurprising genetic link between kidney defects and neurodevelopmental disorders in kidshttp://www.sciencedaily.com/releases/2012/11/121115132342.htm About 10 percent of kids born with kidney defects have large alterations in their genomes known to be linked with neurodevelopmental delay and mental illness, a new study has shown.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132342.htmEven moderate drinking in pregnancy can affect a child's IQhttp://www.sciencedaily.com/releases/2012/11/121114172833.htm Relatively small levels of exposure to alcohol while in the womb can influence a child's IQ, according to a new study using data from over 4,000 mothers and their children.Wed, 14 Nov 2012 17:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121114172833.htmGene nearly triples risk of Alzheimer's, international research team findshttp://www.sciencedaily.com/releases/2012/11/121114171710.htm A gene so powerful it nearly triples the risk of Alzheimer's disease has been discovered by an international team of researchers. It is the most potent genetic risk factor for Alzheimer's identified in the past 20 years.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171710.htmDiscovery could lead to faster diagnosis for some chronic fatigue syndrome caseshttp://www.sciencedaily.com/releases/2012/11/121114171708.htm For the first time, researchers have landed on a potential diagnostic method to identify at least a subset of patients with chronic fatigue syndrome - testing for antibodies linked to latent Epstein-Barr virus reactivation.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171708.htmResearch breakthrough could halt melanoma metastasis, study suggestshttp://www.sciencedaily.com/releases/2012/11/121114153227.htm In laboratory experiments, scientists have eliminated metastasis, the spread of cancer from the original tumor to other parts of the body, in melanoma by inhibiting a protein known as melanoma differentiation associated gene-9 (mda-9)/syntenin.Wed, 14 Nov 2012 15:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114153227.htmPig genomes provide massive amount of genomic data for human healthhttp://www.sciencedaily.com/releases/2012/11/121114134512.htm Researchers provide a whole-genome sequence and analysis of number of pig breeds, including a miniature pig that serves a model for human medical studies and therapeutic drug testing.Wed, 14 Nov 2012 13:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121114134512.htmRare parasitic fungi could have anti-flammatory benefitshttp://www.sciencedaily.com/releases/2012/11/121114134054.htm Caterpillar fungi are rare parasites found on hibernating caterpillars in the mountains of Tibet. For centuries they have been highly prized as a traditional Chinese medicine - just a small amount can fetch hundreds of dollars.Wed, 14 Nov 2012 13:40:40 ESThttp://www.sciencedaily.com/releases/2012/11/121114134054.htmCancer therapy: Nanokey opens tumors to attackhttp://www.sciencedaily.com/releases/2012/11/121114113803.htm There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart of the target.Wed, 14 Nov 2012 11:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121114113803.htmHigh sperm DNA damage a leading cause of 'unexplained infertility', research findshttp://www.sciencedaily.com/releases/2012/11/121114113235.htm New research has uncovered the cause of infertility for 80 per cent of couples previously diagnosed with 'unexplained infertility': high sperm DNA damage.Wed, 14 Nov 2012 11:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114113235.htmA risk gene for cannabis psychosishttp://www.sciencedaily.com/releases/2012/11/121114083928.htm The ability of cannabis to produce psychosis has long been an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a serious psychotic disorder. Further, with the advent of medical marijuana, a new group of people with uncertain psychosis risk may be exposed to cannabis.Wed, 14 Nov 2012 08:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121114083928.htmBacterial DNA sequence used to map an infection outbreakhttp://www.sciencedaily.com/releases/2012/11/121113214635.htm For the first time, researchers have used DNA sequencing to help bring an infectious disease outbreak in a hospital to a close. Researchers used advanced DNA sequencing technologies to confirm the presence of an ongoing outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a Special Care Baby Unit in real time. This assisted in stopping the outbreak earlier, saving possible harm to patients. This approach is much more accurate than current methods used to detect hospital outbreaks.Tue, 13 Nov 2012 21:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121113214635.htmGenetic variation may modify associations between low vitamin D levels and adverse health outcomeshttp://www.sciencedaily.com/releases/2012/11/121113161506.htm Findings from a study suggest that certain variations in vitamin D metabolism genes may modify the association of low serum 25-hydroxyvitamin D concentrations with health outcomes such as hip fracture, heart attack, cancer, and death.Tue, 13 Nov 2012 16:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121113161506.htmNew type of bacterial protection found within cells: Novel immune system response to infections discoveredhttp://www.sciencedaily.com/releases/2012/11/121113143656.htm Biologists have discovered that fats within cells store a class of proteins with potent antibacterial activity, revealing a previously unknown type of immune system response that targets and kills bacterial infections.Tue, 13 Nov 2012 14:36:36 ESThttp://www.sciencedaily.com/releases/2012/11/121113143656.htmGlutamate neurotransmission system may be involved with depression riskhttp://www.sciencedaily.com/releases/2012/11/121113134807.htm Researchers using a new approach to identifying genes associated with depression have found that variants in a group of genes involved in transmission of signals by the neurotransmitter glutamate appear to increase the risk of depression.Tue, 13 Nov 2012 13:48:48 ESThttp://www.sciencedaily.com/releases/2012/11/121113134807.htmTargeting downstream proteins in cancer-causing pathway shows promise in cell, animal modelhttp://www.sciencedaily.com/releases/2012/11/121113134230.htm The cancer-causing form of the gene Myc alters the metabolism of mitochondria, the cell?s powerhouse, making it dependent on the amino acid glutamine for survival. Depriving cells of glutamine selectively induces programmed cell death in cells overexpressing mutant Myc. Using Myc-active neuroblastoma cells, a team three priotein executors of the glutamine-starved cell, representing a downstream target at which to aim drugs. Roughly 25 percent of all neuroblastoma cases are associated with Myc-active cells.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134230.htmEven low-level radioactivity is damaging, scientists concludehttp://www.sciencedaily.com/releases/2012/11/121113134224.htm Even the very lowest levels of radiation are harmful to life, scientists have concluded, reporting the results of a wide-ranging analysis of 46 peer-reviewed studies published over the past 40 years. Variation in low-level, natural background radiation was found to have small, but highly statistically significant, negative effects on DNA as well as several measures of health.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134224.htm

Source: http://www.sciencedaily.com/rss/health_medicine/genes.xml

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After Sandy, lower Manhattan limps back to life

In this Friday, Nov. 23, 2012 photo, a worker wearing protective clothing, behind window, works inside the Heartland Brewery at New York's South Street Seaport, as bags of garbage from the Superstorm Sandy cleanup sit out front. The South Street Seaport, a popular tourist destination, remains a ghost town since the storm. (AP Photo/Tina Fineberg)

In this Friday, Nov. 23, 2012 photo, a worker wearing protective clothing, behind window, works inside the Heartland Brewery at New York's South Street Seaport, as bags of garbage from the Superstorm Sandy cleanup sit out front. The South Street Seaport, a popular tourist destination, remains a ghost town since the storm. (AP Photo/Tina Fineberg)

In this Friday, Nov. 23, 2012 photo, barricades close off a section of New York's South Street Seaport. The South Street Seaport, a popular tourist destination, remains a ghost town since the storm. (AP Photo/Tina Fineberg)

In this Friday, Nov. 23, 2012 photo, people walk past boarded up shops at New York's South Street Seaport. The South Street Seaport, a popular tourist destination, remains a ghost town since Superstorm Sandy. (AP Photo/Tina Fineberg)

In this Friday, Nov. 23, 2012 photo, a dehumidifier, parked on Front Street near Wall Street in New York, blows dry air into the basement of a nearby building. Parts of lower Manhattan?s Financial District are still laboring to recover nearly a month after Superstorm Sandy. A real estate consulting firm says that of the nearly 50 office buildings shut down after Sandy buffeted the Financial District, about half have reopened. Some of the others that are home to large financial and law firms still could be closed for weeks, if not months. (AP Photo/Tina Fineberg)

In this Friday, Nov. 23, 2012 photo, chief engineer Mike Lahm stands inside the damaged basement of 120 Wall Street in New York. The basement was totally submerged during Superstorm Sandy. Parts of lower Manhattan?s Financial District are still laboring to recover nearly a month after Sandy. A real estate consulting firm says that of the nearly 50 office buildings shut down after Sandy buffeted the Financial District, about half have reopened. Some of the others that are home to large financial and law firms still could be closed for weeks, if not months. (AP Photo/Tina Fineberg)

(AP) ? The hum of massive mobile generators, boilers and pumps emerges blocks from Manhattan's Financial District and turns into a steady din south of Wall Street ? the now-familiar sound of an area laboring to recover from Superstorm Sandy.

Other parts of the city have gotten mayoral visits and media attention after the Oct. 29 storm killed dozens of residents and tore apart homes in coastal neighborhoods. Less obvious were the millions upon million gallons of sea water that wreaked havoc on subterranean electrical panels and other internal infrastructure throughout lower Manhattan, making them unusable even after power was restored to the area.

"There were waves on Wall Street, and it all ended up here," Mike Lahm, a building engineer who rode out the storm at 120 Wall Street, said during a recent tour of the skyscraper's basement.

Nearly a month later, some of the high-rises that are home to investment banks, large law firms and luxury apartments have bounced back quickly. But others buildings remain eerily dark and vacant.

Landlords have warned full power won't be back for weeks, if not months, leaving businesses and residents displaced and uncertain about when ? and even whether ? they'll return. JP Morgan Chase, the Daily News and the American Civil Liberties Union are among tenants still operating in satellite locations after getting washed out of their headquarters in lower Manhattan.

Heavy flooding also hit a complex of multimillion-dollar apartments along the Hudson River, whose well-heeled owners ? reportedly including Gwyneth Paltrow and Meryl Streep ? could quietly retreat to second or third homes on higher and drier ground.

"What you're looking at here is a mass exodus," downtown resident Gail Strum said as she retrieved some files and other belongings from a rental apartment building that's still without power. "It feels like there's no coming back."

On paper, Strum's assessment sounds too pessimistic. The city Buildings Department declared only nine buildings in lower Manhattan unsafe because of structural damage from the storm, and the power company, Consolidated Edison, says all buildings citywide had access to electricity and steam power by Nov. 15.

A real estate consulting firm that's tracking the lower Manhattan recovery, Jones Lang LaSalle, says 49 of the 183 office buildings in the business district were closed because of mechanical failures. By the latest count, at least half were back in full operation, even if it has meant relying on temporary power. More are expected to follow.

"We see that as a very healthy pace," said John Wheeler, a Jones Lang LaSalle executive.

One success story was 120 Wall Street, a 600,000-square-foot, 34-story skyscraper built near the East River that's home to nonprofits such as the National Urban League, the United Negro College Fund and the Eye-Bank for Sight Restoration.

Even before Sandy hit, landlord Silverstein Properties got ahead of a scramble for recovery resources by securing portable diesel generators each capable of providing 2 megawatts of power. Afterward, the building brought in its own fuel tanker from Pennsylvania ? and a security team from Florida to guard it ? so it could keep the generators going during the gas crunch.

Using a mix of generator power and restored Con Ed service, engineers had the elevators, lights and heat up and running by mid-November.

To the tenants, "It's as if the building's operating normally," said Jeremy Moss, a vice president with Silverstein Properties.

What tenants don't see in the bowels of 120 Wall Street is a thicket of temporary, exposed wiring that runs everywhere. The warning "LIVE WIRE. KEEP OUT" is spray-painted in red on the door of a room housing switches, fuses or circuit breakers after it was submerged. The air is clammy and musty ? "the smell of the East River," said Lahm, the building engineer.

Fearing the East River might one day try again to meet the Hudson, 120 Wall Street and other buildings are facing an even bigger, more expensive job: Moving critical infrastructure to higher floors or even roofs.

"We're going to need to relocate equipment so history doesn't repeat itself," Moss said.

Farther uptown, NYU Langone Medical Center and Bellevue Hospital Center had put generators on high floors where they could be protected in a flood. But they still suffered failures with Sandy, apparently because other critical components of the backup power system, such as fuel pumps and tanks, remained in basements just a block from the East River.

While 120 Wall Street enjoys a degree of normalcy, other newer and taller glass towers around it remain shut as teams of contractors and workers struggle to restore power, phone and other services. Tractor-trailers providing emergency services such as "microbial remediation" crowd the streets. Cabs are few.

Fire engines became a part of the mix on Friday with the report of a fire in the basement of another vacated office building at 55 Water St. ? the address for financial services company Standard & Poor's and the city Department of Transportation ? that left two dozen people suffering from smoke inhalation and sent four to a hospital. The cause wasn't immediately clear.

The lower Manhattan disarray has also reached the courtroom. Last week, a resident of a still-evacuated luxury high-rise filed a $35 million lawsuit against his condo board and management company, accusing them of "gross negligence" in the wake of Sandy.

The management company, Cooper Square Realty, fired back in a letter from its chief executive, David Kuperberg, claiming that contractors recruited from as far away as Wisconsin and Michigan have been working nonstop to tear out wet walls, carpeting and wallpaper to prevent mold; installing new generators; rebuilding a water pump; and mopping up residue left by oil-tainted salt water.

"While Cooper Square Reality did not cause the storm, the company is doing everything it can" to get people back in their homes, Kuperberg wrote.

The uncertainty also is evident at South Street Seaport, a cluster of early 19th-century mercantile buildings converted to retail shops and apartments. Usually teeming with tourists, the seaport remained a ghost town late last week, despite postcard-perfect weather.

Inside a shut-down brew pub still without lights, workers wearing masks and white jumpsuits scrubbed down the bar, floor and tables. Many businesses, including Ann Taylor, Body Shop and Guess outlets, were still boarded up with plywood.

Also shuttered was "Bodies ... The Exhibition," the show featuring dissected human cadavers that has been a fixture there since 2005. Its website says that due to "damage to our venue, we are closed until further notice."

Some seaport residents have electricity back but no heat or hot water. Liz McKenna, 54, who was living in a third-floor apartment overlooking the East River when a deluge filled the entire first floor with water, said she expects to be able to move back in a couple of weeks ? maybe.

"That's only a guess," she said as she picked up her mail. "Look around. Nobody really knows how bad it is down here. ... We've been ignored."

One of the few businesses to open its doors, Meade's bar and restaurant, had no customers at lunchtime.

"We're open, but who are we open for?" said 28-year-old bartender Nichole Osborne. "All of my regulars are displaced."

An etching on the front window, quoting Dylan Thomas, offered a glimmer of resolve: "Rage, rage against the dying of the light."

___

Associated Press writer Jennifer Peltz contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-11-26-Superstorm-Lower%20Manhattan/id-992e73992b1b4c78a0c5ba689b283b6b

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Weekly Photo Challenge : Thanksgiving ? because writing is her ...

I?m living with this view for more than 20 years. This has been the constant morning picture from my room ever since my family moved away from my grandparent?s compound. Back then, my grandma won a significant amount of money in the local lottery. No, grandma didn?t get the jackpot million prize. How I wish! The money was just enough to give my grandparents a source of steady livelihood and enough inheritance for their children. My father used his inheritance to purchase our home for more than 20 years.

I never noticed this view as I was growing up. In my elementary years, I have to wake up before the sun is up for school. Back in college, I either wake up early or get up late because of my classes that lasts until 9 pm. I never noticed this blessing all those years of my life.

When did I start to notice and appreciate the view? A few months ago while I was savoring my rare vacation from work. I was worried, irritated and can?t find reasons to get up from bed. I pushed away my curtains and I realized, wow this could be a perfect upload for Instagram! LOL

Seriously, that morning made me realize that I tend to ignore a lot of things that I should have been thankful for. I allowed all the negativities in life to control me.

So starting today, I?ll try my best to appreciate this little heaven that never left me all those days of my life.

Source: http://shewantstowrite.wordpress.com/2012/11/26/weekly-photo-challenge-thanksgiving/

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